The Vitamin D Receptor

The calciferol receptor (VDR) is a trans-acting transcriptional regulatory factor. It truly is expressed in the intestines, kidneys, skin, bone tissue, and a variety of defense cells. VDRs have been regarded as being a potential system by which vitamin D influences calcium absorption inside the gut, cellular division, and bone tissues maintenance.

In the nucleus, the VDR is usually phosphorylated upon serine residues by a amount of protein kinases. When ligand binding arises, the molecule triggers multiple intracellular signaling pathways that are independent of the goal gene transcription process.

The vitamin D receptor is a member of the superfamily of trans-acting transcriptional regulating factors. It has a zinc finger DNA-binding domain, a ligand-binding sector, and a transcriptional service area. These elements are essential for the protein’s efficient activity.

The cDNA related to the calciferol receptor was isolated by a human intestinal cDNA archives. RNA mark hybridization for the cDNA exposed a single RNA species of regarding 4. 6th kb.

VDR expression is found in numerous cell types which include epithelial skin cells, glial fibrillary acidic protein, dendritic cells, platelets, neutrophils, macrophages, and oligodendrocytes. Research using confocal microscopy have demonstrated VDR indivisible staining in many different cellular cultures.

Some studies have investigated the effects of VDR variants about osteoporosis and BMD. Nevertheless , these research have been limited in their test size and have been inconclusive.

Meta-analyses of genetic association research have also found heterogeneity. This may be a result of hidden stratification belonging to the populations trained in.